The Molecular Indices of Metal Stress (MIMS) technique measures the amount of metals present in various hepatic cellular protein pools, and uses changes to these levels as indicators of metal stress. The base unit of the analysis is the MIMS ratio, which is the ratio of cytosolic metal levels to the total cellular metals. Data were collected from a number of studies throughout B.C. examining the livers of wild rainbow trout and cutthroat tout, naive trout held in situ, and naive trout used in chronic bioassay studies. The values of MIMS ratios as a single numerical indicator of metal stress appear to be limited. The mean MIMS ratios for three uncontaminated lakes were significantly different for all metals tested (P<0.001). There appeared to be a potential value for the MIMS technique when membrane-bound and cytosolic metal levels were compared to total metal levels using least squares regression. Data from uncontaminated lakes often showed strong relationships, suggesting the hepatic cells were coping with
Nordin, Dr. Richard. 1993. The Value of the Molecular Indicators of Metal Stress (MIMS) Technique in the Analysis of Aquatic Metal Stress in Fish. BC Ministry of Environment
Keywords: MIMS, molecular indices of metal stress, technique
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